I bought G4 PAMAM dendrimer from a company but they aggregated. The size of them changed from 5nm to 100nm and I cannot work with them because the NH2 functional groups of dendrimers are not available for a chemical reaction. Please guide me, how can I separate PAMAM dendrimers? Is there any pretreatment?
Dear Zahra Nazemi, you can break down aggregates by sonication, but you should first check literature for possible degradation. My Regards
Many thanks,
Did you have any experience with it? or Do you have any suggestions about the sonication conditions?
No thanks, we have experience with sonication but with PAMAM. According to the attached file, PAMAM is not suspected to form aggregates but its derivatives yes. Good Luck
Hi,
I totally agree with Pr. BOUAZIZ, you can use ultrasound for the deagglomeration of coarse particles.
With my best regards
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