Dear Haritha Nayanajith

I would answer you in simpler form.

1. Prednisolone is slightly soluble in water, soluble in 27 parts of absolute ethanol, in 30 parts of ethanol, in 50 parts of acetone, and in 180 parts of chloroform. It is soluble in dioxane and methanol

2. Lactose monohydrate Solubility : Soluble in water (warm) (0.1 g/mL), and ethanol (very slightly soluble). Insoluble in chloroform, and ether.

3. Sodium Starch glycolate: Practically insoluble in water and gives a translucent suspension. Insoluble in most of the organic solvents.

4. Stearic acid is a saturated fatty acid that can deposit on the surface in special conditions. This acid is insoluble in water and soluble in ethanol.

5. Magnesium stearate: Very soluble in water, in alcohol, and in ether; practically insoluble in chloroform.

6. Microcrystalline cellulose can be dispersed but insoluble in water, insoluble in dilute acid, organic solvent and oil, swollen in dilute alkali solution, partially dissolved.

7. Pregelatinized starch. It is a white crystalline compound, insoluble in water but soluble in alcohols, chloroform, dimethyl sulfoxide and aqueous polyethylene glycol

Solution. As from this data, you can do one thing, crush the tablet and at first mix it in chloroform, vortex and sonicate for 15 min, add water again repeat vortex and sonication; discard water layer, centrifuge chloroform layer, vaporize it and reconstitute it with mobile phase as per HPLC method of prednisolone and compare the concentration with standard. This method will give you robust solutions. have a good day