I have tried to remove NaCl using dialysis. It is working but it takes a long time. Is there any alternative method for this?
Dear Yogesh,
You may try to lyophilize and dissolve the residue with polar organic solvents that might extract the other organic compounds and leave NaCl as a precipitate. Another possibility is vacuum evaporation and extraction by polar organic solvents. If these two methods turn to be unsuccessful to try to use a resin such as XAD-2 and make eluation with alcoholic solvent or other polar organic solvents.
Hoping this will be helpful,
Rafik
You can use dialysis membrane to remove NaCl from high molecular weight molecules by using a proper cut-off molecular weight membrane.
Dear
You can read the manuscript as Extraction and Washing Guide at the following link: http://ocw.mit.edu/courses/chemistry/5-301-chemistry-laboratory-techniques-january-iap-2012/labs/MIT5_301IAP12_Work_Handout.pdf.
Another method could be helpful as: Salting-out Liquid-Liquid Extraction
at this link http://www.chromatographyonline.com/salting-out-liquid-liquid-extraction-salle.
Good luck
desalting columns are the best and faster option if your compound is bigger than 3000 dalton
what if you use an alcohol such as ethyl alcohol in which the salt is slightly soluble in it?
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