I am currently looking for ways to develop the photocatalytic accessibility of various drug-like frameworks for application in light-driven functionalization and late-stage diversification. The attached structures encompass indole-based frameworks, piperidine-connected heterocycles, isoquinolines, and extended π-conjugated systems — all with untapped potential for photocatalysis in drug elaboration, especially CNS-targeted drug discovery. My personal interest is in: Facilitating single electron transfer (SET) and hydrogen atom transfer (HAT) reactions Developing scaffolds that can undergo C–H activation, Minisci-type alkylation, or photoredox cross-coupling Introduction of halogen handles (e.g., Br, I) for visible-light-mediated reactions Increasing π-conjugation to facilitate energy transfer and absorption in the visible region Use of photoresponsive groups or redox-active sites for radical activity Key questions: 1. What are the optimal positions on these scaffolds for the introduction of halogen or redox-active groups? 2. What structural features are responsible for effective interaction with common photocatalysts (e.g., Ir(ppy)₃, Ru(bpy)₃²⁺, 4CzIPN)? 3. Are there scaffold-hopping approaches that would retain biological activity and maximize photocatalyst interaction? If you have a background in visible-light functionalization, photopharmacology, or medicinal photochemistry, I would appreciate any tip on molecular modifications, protecting groups, or docking-friendly modifications. Thank you in advance!