How can i know the significance of Jc1 mitochondrial membrane potential ?

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Rahul Kumar

JC1 staining is not a direct assay for apoptosis. You need to perform Annexin labeling for that.

José Luis Duque-Rivera

The mitochondrial depolarization that is detected with the fluorescent probe JC-1 is an early event of cells that eventually develop apoptosis. But this depolarization does not always trigger cell death, it could be a transitory process in which there can be mitoncondrial selection as a defense mechanism against moderate levels of reactive oxygen species.