How can I interpret similar observations from acute and chronic treatments?

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Dennis Mazur

Here is a potential set of interpretations based on the information you have provided:

1. Both treatments elicit the same placebo response.

2. Both treatments have the same efficacy at the doses used.

3. Dosage1 treatment and Dosage2 treatment come from different bottles with different expiration dates.

Dennis

Elham Amini. E.A

Thanks alot Dear Dennis for your reply.

Actually, both treatments (acute and chronic ) were applied in the animal study. In addition, we used the same drug for both treatments, but with different doses and frequency. Thus, the both drugs were taken from the same resource with the same expiration date.

I did these treatments to reduce inflammation in animals, but surprisingly, I observed similar results for both acute and chronic doses. Now, I am interested in knowing how it happened.

CLARIFICATION OF TERMS

Let us see if we agree on definition of terms "acute" and "chronic":

1. acute vs. chronic

1.1 An "acute injury" happens at one point in time, treated soon thereafter, and not allowed to continue into a chronic state.

1.2 However, if the acute treatment is ineffective, the acute injury continues over time and develops into a "chronic condition".

1.3 A treatment to be effective must show "at least some partial improvement". However, a partial treatment may "lose efficacy"and go back to the original state as if no treatment was ever applied.

Shibabrata Pattanayak

Dear Dr. Amini,

Perhaps the most minimum dose of the drug you selected is still high for the experimental animal species.

If you are a student of Pharmacology, you know there is a guideline of selection of doses in different animal species for experiments.

Follow this one as effective dose. Then take doses below this and above this.

Try to perform your experiments on two species of lab animals (as rat/ mice and rabbit).

I think you will be able to solve the problem.

Thanks.

Dear Dr Dennis,

I really appreciate. I got good points from your comments.

Dear Dr. Shibabrata Pattanayak

Thanks for your comment. Actually, before starting the main study, a pilot study has been done. Based on this, dose and time responses already done and optimum dose and time was determined.