I'm preparing polymeric nanoparticles using emulsification solvent evaporation method, but I haven't got the characteristic emulsion that indicates the nanoparticles formation.
by optimizing concentration of surfactant, oxidizer, and monomer concentration.
I guess by characteristic emulsion you meant stable suspension of nanoparticles. Try to vary the surfactant concentration or else use some other like PVA, SDS etc. Also, try to measure the zeta-potential of the final system to have better insight in the stability of the NP.
The formation of nanoparticles can be optimized by changing different variables such as solvent, type of surfactant and its concentration.
Only for the synthesis of monodisperse polymer microspheres, you can try to use the other synthetic techniques. There are many methods in this field. You can select the suitable one, which depends on the monomers.
Hello everyone
Dear Barbara: when I wrote "ccharacteristic emulsion" I mean a milky suspensión, but I got two phases (water and organic phase separately).
Dear Vibhore: you're right, I have been using 0.5 %w/w Poloxamer as a surfactant. And I had though in changing that concentration.
Dear Xinlin: today I tried to use double emulsion solvent evaporation technique (I hace read that that technique may be used to encapsulated hydrophobic drugs) , but, It was obviously so difficult to dissolved an hydrophobic drug in water.
Could you please advice me in double emulsion solvent evaporation technique articles ??
Thank you so muchos forma your answers... !!!!
Try this paper, it is all about double emulsion technique.
http://dx.doi.org/10.1016/j.biortech.2013.01.106
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