COMSOL allows you to sweep over different parameters when you are solving a case. You can define it in the parameter node (Global Definitions, Parameters), use that parameter at boundary condition, or wherever you have a variable instead of a constant, and assign values to it in the Study node. However, your parameters of interest cannot be applied directly as boundary condition. Instead, you can convert them to appropriate parameters. For example, if you are modeling the flow in a channel, define Re as a parameter, use the relationship between Re and flow rate, or velocity and in the boundary condition, instead of flow rate, insert Re*mu*A/(rho*Dh), where viscosity, cross section area, density, and hydraulic diameter are constant, and Re is your variable. Similar procedure for other non-dimensional numbers. Then, assign you Re values of interest in the Parametric Sweep section of Study.