Please guide me to find the SNPs of a specific gene region, for example, a specific region of the CYP2D6 gene, How can I find? and which way is good? I tried SNP database for NCBI but I couldn't found.
Thank you,
SNPs and other genetic differences are included in the extensive database known as dbSNP, which is made available by the National Centre for Biotechnology Information (NCBI). Using the gene name or the gene's genomic coordinates, you may look for SNPs in certain genes. So, you can search for SNPs within a specific region of the CYP2D6 gene by providing the gene name or its genomic coordinates (chromosome number, start position, and end position). Also, the Exome Aggregation Consortium (ExAC) (https://gnomad.broadinstitute.org/) is a coalition of investigators seeking to aggregate and harmonize exome sequencing data from a variety of large-scale sequencing projects, and to make summary data available for the wider scientific community. Hope this is helpful.
Hi Hokmabadi,
May I know if you mean to find SNP on known region? If yes, I have the similar experience. I use the NCBI in which all SNPs in specific gene can be shown.
1. Open the home page for NCBI. In the drop-down list, choose "Gene" and enter the gene name like CYP2D6 in the field and search.
2 Please choose the suitable option for human gene in the first result.
3 Please scroll down to find the button "GenBank" and click it. Then you will skip to new page and please enter the target region position on right column and click "update view".
4 Finally, please click the button "Graphics" at the top of the page. Then you can see all SNPs with rs number and red line in target region.
Hope this is wanted guideline.
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