hello,  I have attached a few links that could help you with your problem.  When we have this problem administering drugs to rats, we use dmso to dissolve the drug and then further dilute this in water to drastically lower the final dmso concentration.  I am not sure rats would like dmso in their stomach but if it was diluted they might not mind it.  Good luck

http://www.dissolutiontech.com/DTresour/200articles/200art3.html

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399483/

http://www.academia.edu/2611991/TECHNIQUES_FOR_SOLUBILITY_ENHANCEMENT_OF_POORLY_SOLUBLE_DRUGS_AN_OVERVIEW

thank you Brandon

Hello,

You can make a suspension of the drug in water using a wetting agent like SLS at 1% concentration. 

If you want to dissolbe it completely, you can use vegetable oils (olive, corn...) because fenofibrate is well dissolved in organic compounds. Similarly, you can use medium chain triglycerides (Mygliol 812) .

Regards

Hello,

In addition to the answer above you can apply a self emusifying delivery system (M.S

unitha Reddy et al. IRJP 2011, 2 (11), 173-177). as alternative you can also make a cyclodextrin complex (beta-cyclodextrin) , to have a water soluble compound.

best

Giorgio

All are good suggestions, but there may be a few problems.  If I remember correctly from work we did with fenofibrate, it is not very soluble even in DMSO. (If I am incorrect, then please forgive my memory!)

Emulsions and surfactants certainly will help to solubilize the drug, but in our work we found that the extreme low water solubility of fenofibrate causes it to partition into the structures-- this leaves a low aqueous concentration so the absorption might still be poor (even though it would certainly be better than just giving the pure API).

I realize this is a last resort kind of suggestion, but a relatively small amount of ethanol (10-20%) would work wonders in terms of actually dissolving the drug into the form that gets absorbed (dissolved free molecules in the aqueous phase)-- that is, provided the ethanol is tolerated or not otherwise excluded from use. 

I wish I had a better suggestion.

Good luck!

Turning the drug into an emulsion or suspension should be OK.  Rats are used for this type of testing because they lack the ability to "throw-up" so you should be able to get the sample into the gut of the rat.  He may not be very happy but should not be able to get the sample our of his or her system.  BTW they do like to bite....

Fenofibrate being a drug without any pKa is a very complex molecule with respect to solubility and thereby challenged permeability issues. The drug tends to aggregate in polar solvents like water and is never a very suitable approach to look forward for alteration in pH and polarity of the solvent to get its in molecular dispersion state. The only answer to your problem in formulation of gavage for preclinical trials can be preparing an emulsified system preferably using low to optimum HLB figure. Also, the addition of external sonication energy to optimize the size of such emulsified carrier can embark the drug payload. The caution need to be taken with respect to the permeability variations or enhancement due to utilization of surfactant, which can be countered if a drug surfactant solution can be kept as a control. Best of luck...

Dissolve in ethylene glycol or glycerol and use it as a solution or even, as a fine suspension. You can dilute with water for the solution in glycerol because of viscosity.

DMSO has analgesic and anti inflammatory activity.

Ethanol has effects on CNS.

You can also prepare a suspension with gum acacia, that diluted to any volume by water.

If proprietary product of fenofibrate is to be administered, solubility issue does not arise as the approved tablet or capsule contains a surfactant and there may be a cellulose suspending agent also, along with the active. If pure drug is used for animal oral administration, the drug can be made into a suspension along with Tween 80 or SLS. The syringeability through the oral needle may not be a problem if it is made into a fine extemporaneous suspension.

Not knowing the purpose of your study, it is a little challenging to answer. As carried out in several of the previous answers, solubilizing agents will help to overcome the solubility issue. A very efficient solubilizing agent for fenofibrate, which at the same time is in current use for oral drug formulations is Labrasol (registerd trademark). At 37 degC in our hands fenofibrate is about a thousand times more soluble in 0.6% aqueous solution of Labrasol as compared to buffer. But, in our experience, many drug compounds are not absorbed better than mere aqueous solutions despite the oftenly tremendously increased concentration of drug in solution. See eg DOI 10.1002/jps.23979 or doi:10.1016/j.ejpb.2011.04.010

thanks martin

DEVELOPMENT AND CHARACTERIZATION OF   FENOFIBRATE SELF­MICROEMULSIFYING DRUG DELIVERY  SYSTEM (SMEDDS) FOR BIOAVAILABILITY ENHANCEMENT  .... This is an interesting article to your problem