Dear colleague

In difficult cases we can use bcl-2 (diffuse staining in bcc, only basal layer staining in trichoepithelioma), CD34 (positive in peritumoral fibroblasts of trichepithelioma not bcc), CD10 (positive as epithelial expression in bcc and stromal expression in trichoepithelioma) and stromlysin-3 (positive in fibroblasts of bcc not trichepithlioma). Refer to Weedon's textbook of skin pathology or other dermatopathology references.

Dear Dr.Mazaher Ramezani,

Thank you for your answer, I had tried bcl-2 and androgen receptor in this differential diagnosis but them did not seem to be useful.

Further to Dr Ramezani's answer:

CD10 is useful: Article CD10 expression helps to differentiate basal cell carcinoma ...

Another study used an array but found it was relatively hard to differentiate

Article Diagnostic utility of immunohistochemistry in distinguishing...

CD10 with Ki67 and PHLDA1 may be more useful

Article Diagnostic Accuracy of Immunohistochemical Markers in Differ...

https://www.jaad.org/article/S0190-9622(15)00467-3/abstract

Cytokeratins 6

Article Immunohistochemistry Panel for Differential Diagnosis of Bas...