Yang et al reported in July issue of Liver Transplantatin the relative contributions of necrotic and apoptotic biomarkers in liver ischemic reperfusion injury in mice. "Biomarkers Distinguish Apoptotic and Necrotic Cell Death During Hepatic Ischemia-Reperfusion Injury in Mice". See abstract at: http://www.ncbi.nlm.nih.gov/pubmed/25046819

A nice recent (2012) review article on pathophysiology of ischemic reperfusion liver injury full text available at:

http://www.hindawi.com/journals/hpb/2012/176723/

A sudden LDH and lactate raising without a systemic deterioration of tissular perfusion may be signs of hypoxic injury of the liver graft.

Hypoxia in hepatocytes after liver transplantation would indicate hepatic artery thrombosis. While there may be number of means to detect this in the experimental setup, clinically useful parameters are rising blood lactate and increased glucose requirement. Acute elevation of serum LDH and transaminases are  other signs. USG Doppler can identify this complication at the bed-side.

Experimental studies have reported the use of micro dialysis catheters placed within the liver graft at the time of surgery as a means of detecting hypoxia early.

We are using microdialysis to detect early hypoxia after liver transplantation in children by using intrahepatic catethers. Increase in lactate and lactate/pyuvate ratio indicates hypoxia/ischemia. Analyses may be performed bedside.

http://www.ncbi.nlm.nih.gov/pubmed/23193034

http://www.ncbi.nlm.nih.gov/pubmed/22407878