I am confused by the role of cAMP on adipogenesis and lipolysis. I know that when cAMP is high, it activates PKA and thus phosphorylates HSL and perilipin A to facilitate lipolysis, and when cAMP, insulin, and glucocorticoid present together, the "cocktail" can induce adipogenesis. But if both procedure require high cAMP concentration, how does the cell decide which way to go? It does not make sense that the cell differentiates and breakdown lipid simultaneously. Also, insulin is supposed to inhibit cAMP production through PI3K pathway, how come that these two show together in the body to stimulate adipocyte differentiation?
If there are any figures that help illustrate this problem, it is more than welcomed.
Dear Xiao,
I think reading the below manuscript about Regulation of Lipolysis in Adipocytes could help to take off your confusion.
Regards
Ehab El-Haroun, PhD
doi: 10.1146/annurev.nutr.27.061406.093734
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