If the tumour develops from epithelial cell it is called carcinoma and if tumour develops from mesenchymal cell then it is called sarcoma. In case of epithelium there is no blood vessels. which means angiogenesis doesn't happen in case of carcinoma? And it should happen only in case of sarcoma. people say that angiogenesis plays a very important role in metastasis. Then how carcinoma cells undergo metastasis? We know that during metastasis the epithelial cells undergo EMT folowed by intravasation. Which means EMT should not happen in sarcoma. Is that the case?
Hello Jayesh. The thing is that "everything is connected". One can not compartmentalize mesenchymal cells and epithelial cells. EMT is named EMT (epithelial mesenchymal transition) because epithelial cells suffer a mesenchymal transition until they metastize somewhere else, and there suffer the reverse process: MET (mesenchymal epithelial transition). So, along the process, several pathways, phenotypes and genes are switch on and off. I don't know if that helps or not for your question.
Hello Carla Lopes. Thanks for your answer. But still I am not really convinced and I didn't get what I am looking for.
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