Dear collegues
I am sure that the metabolites of microbiome make a special microenvironment for the division, diffenrentiation and function as well as the death of the gut endotelial cells . The machinery of the pathogene-induced inflammation and immune protection against the pathogens is rather well investigated. What can you say about the action of the "good" mictobiome and its translocation through the healthy gut burrier for the processes mentioned above? If you have the articles aboiut it I'll be happy to get them.
Hi
Healthy microbes can easily turn rogue. Those in our guts are undoubtedly helpful, but if they cross the lining of the intestine and enter our bloodstream, they can trigger a debilitating immune response. The same microbes can be beneficial allies or dangerous threats, all for the difference of a few millimeters.
Conversely, “unhealthy” configurations of microbes can be normal, even necessary. Ruth E. Ley at Cornell University and colleagues demonstrated this in dramatic fashion when they found that microbiomes go through a huge upheaval by the third trimester of pregnancy. They end up looking like the microbiomes of people with metabolic syndrome — a disorder that involves obesity, high blood sugar and a higher risk of diabetes and heart disease. These communities might indicate someone on the verge of chronic disease — or merely motherhood. Packing fat and building up blood sugar makes sense when you are nourishing a growing fetus.
another example. Common medical wisdom says that healthy vaginal microbiomes are dominated by the acid-making Lactobacillus group that creates an inhospitable environment for disease-causing microbes. But Larry J. Forney at the University of Idaho and colleagues found that a quarter of women didn’t fit this pattern, despite being perfectly healthy. They also showed that their vaginal communities can change dramatically and rapidly, even over a single day, flitting in and out of states that are supposedly conducive to disease, but with neither clear causes nor ill effects.
Hi! Thank you for the references and your opinion !!! I can confirm that in the third trimester of pregnancy (in mice the changes of the barrier functions of the linnen of the gut is the reason of the generalisation of Klebsiella pneumonia in the broot.
- Badges
- Science topic
- Similar topics
- Methodology
- Research Methodology
- Research Papers