I need efflux pump inhibitors (EPIs) against AcrAB and OqxAB pumps in Klebsiella pneumoniae. From literature, I came to know that naphtylmethyl-piperazine (NMP) is a well characterized EPI in Gram-negative bacteria for RND-type category of efflux pumps which both AcrAB and OqxAB belong to. Can someone please tell if I can use NMP and will it work against both pumps?
Naphtylmethyl-piperazine (NMP) is a known efflux pump inhibitor (EPI) effective against RND-type efflux pumps, including AcrAB and OqxAB, in Gram-negative bacteria like Klebsiella pneumoniae.
Studies have shown that NMP can inhibit both AcrAB and OqxAB efflux pumps, enhancing antibiotic susceptibility in K. pneumoniae. However, the effectiveness of NMP against both pumps may vary depending on the specific strain, experimental conditions, and antibiotic used.
To confirm efficacy, I recommend reviewing relevant studies and consulting experts in the field. Additionally, in vitro and in vivo experiments can be conducted to evaluate NMP's inhibitory activity against AcrAB and OqxAB in your specific K. pneumoniae strains.
Keep in mind that EPIs like NMP may have limitations and potential toxicity, so further research and careful consideration are necessary before exploring their therapeutic applications.
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