It almost appears you have an air bubble in the detector or an electrical surge. Is it always present at the same RT? If an air bubble, flush your system with 100% warm and degassed water (no column) at 5 mL/minute for 5 minutes. If electrical, install a 'surge' protector between the HPLC and the electrical outlet.
Hi Nadia. Could you change the y scale in your software? I can't see your baseline in your chromatogram. It's difficult analyse what is happen in your HPLC system with this photo.