Genetic marker have some role in predicting risk of stroke in this condition. Spontaneous apoptosis of smooth muscle cell in the atherosclerotic plaque combined with inflammation contribute to thinning of fibrous cap. Polymorphosims of CRP, I L-6,ICMP-1and MMP-3 are studied as a risk factors of stroke in these patients. Genetic Polymorphosims of coagulation factors also have important role.