Hi, I have a project about using the micropatterns substrate to see the hMSCs behavior and the differentiation fate. the project goals is to find out whether the micropatterning can lead the direct differentiation of MSCs to become chondrocyte lineage. So are there any specifications of the micropatterns especially to enhance and direct the hMSCs becomes chondrocyte lineage?some references or research articles link related to this project may be helpful. Thank you.
I've done some work on this before but it's been awhile. Wrote a paper Fabrication of polymeric substrates with micro- and nanoscale topography bioimprinted at progressive cell morphologies, should be full text on here. A good contact would be Tim Woodifeld who has done more work in this area.
Article Fabrication of polymeric substrates with micro- and nanoscal...
Hello
Also look at these links
Good Luck
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601118/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4865671/
http://file.scirp.org/pdf/JBiSE_2013012916320705.pdf
http://www.nature.com/articles/srep03552
Hi, you can try my old department, they have publications on micro/nano patterning on stem cells at glasgow university tissue engineering. Check Mathis Rhiele, Matt Dalby publications they have extensive studies on stem cells and surfaces.
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