We are running a systematic review of methods used to assess toxicity from glucocorticoids in inflammatory conditions (Prospero registration: CRD42022346875). We are in the process of screening and selecting papers for full-text review. As part of the quality appraisal we are thinking using the MAPP tool but several studies (e.g., DOI: 10.1111/jep.12884, DOI: 10.1016/j.jclinepi.2019.03.008) present some conflicting findings as for the tool's usefulness. Studies conclude that Additional validation research on the MMAT is still

needed. In our review we will include some mixed methods studies but most quantitative studies (e.g., RCT, observationals, cross-sectionals, validation, etc.). Given the broad nature of the study, we think this tools deemed appropriate, yet, we doubt as for its sound efficacy. Any previous experience or thoughs, would be much appreciated.

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