The Dot-Probe task has been widely used in research on affective disorder and addiction in human subjects. Briefly, the subject has to choose one of two buttons to indicate in which of two locations a dot appears, where the two locations are jointly preceded by presentation of drug/spider etc image on one side, and a neutral image on the other. The latency to respond to the side contralateral to the clinically-relevant image is interpreted as a measure of attentional bias.
I'm wondering if anyone has developed a task like this for rodents, to see whether presentation of a drug-conditioned CS+ in a spatial part of the animal's environment delays/distracts an operant response unrelated to the drug in another spatial location.
Dear James,
Neurobiol Learn Mem. 1995 Mar;63(2):116-32.
Spatial working and reference memory in rats bred for autonomic sensitivity to cholinergic stimulation: acquisition, accuracy, speed, and effects of cholinergic drugs. Bushnell PJ, Levin ED, Overstreet DH.
....This study was conducted to determine whether the selected differences in cholinergic autonomic sensitivity would be expressed as differences in cognitive ability based on choice accuracy in appetitive tasks. The working and reference memory of rats of these two strains was thus assessed using operant delayed matching-to-position/visual discrimination (DMTP/VD) and the radial-arm maze. A Long-Evans (L-E) reference group was included in the DMTP/VD study.----
J Exp Anal Behav. 2014 Nov;102(3):346-52. .
Responding by exclusion in Wistar rats in a simultaneous visual discrimination task. Felipe de Souza M, Schmidt A.
Selective cognitive deficits in adult rats after prenatal exposure to inhaled ethanol. shiro WM et al. 2014
The effects of acute pharmacological stimulation of the 5-HT, NA and DA systems on the cognitive judgement bias of rats in the ambiguous-cue interpretation paradigm. ygula R, Papciak J, Popik P. ur Neuropsychopharmacol. 2014 Jul;24(7):1103-11
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