I worked on Quercetin to target colon cancer as oral drug delivery system. I performed simulated studies.

Check the following link

https://www.researchgate.net/post/which_solvent_is_suitable_for_quercetin_solubility

could you tell me how to dissolve it @raji rajeswari kamisetti

thanks for your interset. I have already checked it but i could not find any solutions for in vivo all talk about in vitro. do you have any experience in quercetin? @ Seyyed Morteza Hoseini

Mahran Emam Did you find how to dissolve the quercetin to use in vivo? I will use it or I want to use it intraperitoneal, and I don't know wich choose, the one thar said Quercetin hydrate, or the one is not, is solid. I will purchase it in Sigma-Aldrich, but it is disconcert to me which I have to purchase.

Dear Mahran, just in case that this interesting technical question is still of interest to you, please have a look at the following potentially useful links about the solubility of quercetin:

COMPOUND SUMMARY Quercetin

and

On the Solubility of Quercetin

https://core.ac.uk/download/pdf/205809123.pdf

(see attached pdf files)

Also please note the the solubility of quercetin has been the subject of various previous discussion on RG, e.g.

Which solvent is suitable for quercetin solubility?

https://www.researchgate.net/post/which_solvent_is_suitable_for_quercetin_solubility

(23 answers)

and

Is Quercetin soluble in (THF) tetrahydrofuran?

https://www.researchgate.net/post/Is_Quercetin_soluble_in_THF_tetrahydrofuran

(3 answers)

In your particular case, i.e. the preparation of a stock solution of quercetin in DMSO + PBS buffer, I would suggest to try either slight warming to 40-50 °C or (even better) sonication. Sonication often leads to dissolution of turbidity in a solution. It can be easily done in a normal ultrasound bath which is normally used for cleaning laboratory glassware. You should give it a try.

Good luck with your work and best wishes, Frank Edelmann

I worked much with quercetin in aqueous solution. The solubility strongly depends on pH. The physiological pH (a blood serum) is 7.4. I used potassium (or sodium) phosphate buffer,

DOI 10.1016/s0076-6879(02)59199-0