Guanylyl cyclase C (GC-C) plays an important role in maintaining fluid ion homeostasis and genomic integrity in intestinal cells and serves as the receptor for the diarrheagenic heat-stable enterotoxin (ST) as well as endogenous ligands guanylin and uroguanylin. The major site of expression of GC-C is in the gastrointestinal tract, although this receptor and its ligands play a role in ion secretion in other tissues as well. Some investigators have suggested that the almost exclusive intestinal expression of GC-C could serve as a marker for colon carcinoma metastasis in tissues other than the gut. Basu et al has shown that GC-C is a substrate for inhibitory phosphorylation by c-src resulting in reduced ligand-mediated cGMP production.
I have to design a project on the GC-C and its consequent affect of CRC carcinogenesis; Can anyone suggest the line of work and which molecule or pathway should we look into?
Hi Aga. What role does GC-C play in the maintenance of genomic integrity? Is there any involvement with folate or TYMS metabolism?
Have a look at the potential of GTP cyclohydrolase interaction with GC-C. The conventional wisdom is that human cells do not possess this activity but diseases in biopterin metabolism suggest that it may not be that straightforward. It may be part of the CRC carcinogenesis story.
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