there are many side effects of chemo and radio therapy for cancer therapy, moreover, one of the main obstacles is cancer recurrence !!! I would like to know, does genomic engineering approach for cancer therapy gives permanent results or there is still a risk of cancer recurrence
I don't think anyone could guarantee that it would 100% of the time, cancer is complex. However it is a promising area for us to pursue.
If gene editing was applied to the very earliest stages of embryonic development (Zygote, maybe blastocyst?), before there are too many cells and you could guarantee that all cells have been transformed, then the change would be passed to offspring.
For a treatment of the multicellular embryo/Child/adult, any gene therapy would have to modify the gametogenic cells in the gonads for it to be inherited. Again, all gametogenic cells would have to be modified to have all gametes with the modification. My understanding is that these therapies are expensive and necessarily targeted to the tissue of interest.
Of course such gene editing could in some cases cause cancer as well if other, unknown/untargeted genes are effected.
DNA changes for a time. This means mutations build up and cancers appear. It would be impossible to not just say the cancer would disappear,as we do not know how these changes appear or even by mathematics. What probability do you have this mutation appearing or why would you have this mutation? We do not know the consequences of these changes, we do not know how would these mutations (beneficial after the editing) freeze, and even even if they change we do not know how. It does solve the problem, but only until the next time. You do not have a cancer after a mutation. It must be several mutations, one of them appears as cancer. Sometimes they do, although the improvements suggest they do not. It is just for the individual. sometimes we do, and we make it like this as it is a terrible mutation. You may if we do not know (all of the cases).
Wenn die Ursachen der Krebsentstehung nicht beseitigt wurden, muss man mit dem Wiederauftreten von Krebs rechnen.
Nach meinen Forschungsergebnissen ist Krebs eine systemische Entzündung, die durch Schadstoffe verursacht wird. Die Entstehung solcher Entzündungen schädigt die Zellgene und fördert das Zellwachstum. Ich habe die Entstehung und die Chronifizierung von Entzündungen durch Schadstoffe sowie deren kausale Behandlungen in Übereinstimmung mit den Gesetzen der Physik, speziell der Thermodynamik, in meiner Publikation beschrieben und damit naturwissenschaftlich nachgewiesen.
Schwerpunkte meiner Arbeit sind die physikalischen Mechanismen der Temperaturerhöhung einer Entzündung, der Gewebeschädigung, des Zellwachstums und der Chronifizierung. Bitte bedenken Sie: Was nach den Gesetzen der Physik richtig ist, ist auch praktisch richtig.
Haben Sie Interesse an meinen physikalischen Nachweisen und den kausalen Behandlungen von Krebs?
Daniel William Hutchins
thank you for your answer. using genome editing might lead to different types of cancer as a result of off-targeting. however, having various types of bioinformatics tools is helpful in predicting it.
and there is another point that, when you detect the particular mutation that involves in the molecular pathway of cancer and corrected by using genomic engineering tools such as Zinc finger or CRISPR Cas system, it would stay for a long period of time!
.... Sdert
cancer is a appears as a result of accumulation of various mutations and have a complex molecular pathway. however, after identifying of those molecular pathway and inhibiting the oncogenic or activating of TSG by using genome engineering can we get a permanent result for ever? or that factors that leads to the previous mutation should be firstly inhibited?!
No,you might still get (a ) mutation. You solve the problem,but you might obtain (different results). Very unlikely you obtain(the same ) result
If the causes of cancer development have not been eliminated, one must expect the recurrence of cancer.
According to my research, cancer is a systemic inflammation caused by pollutants. The development of such inflammation damages cell genes and promotes cell growth. I have described the development and chronification of inflammation caused by pollutants as well as their causal treatments in accordance with the laws of physics, especially thermodynamics, in my publication, thus providing scientific evidence.
The focal points of my work are the physical mechanisms of the temperature increase of inflammation, tissue damage, cell growth and chronification. Please remember: What is correct according to the laws of physics is also correct in practice.
Are you interested in my physical proofs and the causal treatments of cancer?
Frank Mitter thanks for your comment, yes it was very internesting
- Badges
- Science topic
- Similar topics
- Linguistics
- Composition Studies
- Publication