Food matrix refer to other components in the food that could synergic effect with macronutrient or micronutrient in food. One review had shown that whole milk had more effect than low fat milk or iso-milk protein for muscle protein synthesis regardless of reach to leucine threshold after exercise. This effect was without reaching to leucine threshold, due to exist of food matrix in whole milk. So I would like to plan this discuss about coffee component. The one of component in coffee that very application in exercise is caffeine and many research discussed about of different dose of caffeine for effectiveness during exercise. But many researches used the caffeine individually and in form of supplement (for example: pills, gum, and etc). Now I want to express this issue, does all of coffee component with together had more synergic effect than individually form of each component? Does synergic effect of coffee component more important than quantities of each components in individually form? For example maybe food matrix of coffee for effectiveness of caffeine more important than dose of caffeine? What’s your idea about food matrix for exercise performance?