Hello,
I am trying to find some literature about protein translocation from the Endoplasmic reticulum to the nucleus but I am unable to find it. The literature mostly points to exocytosis or misfolded protein degradation in lysosomes for proteins exiting ER.
I was able to find a few papers that describe how EGFR and ERBB3 transport to the nucleus using endocytosis as a reverse mechanism of entry and after merging with ER these transmembrane proteins travel across the ER-nucleus membrane until they reach the nuclear pore and enter. This is the closest thing I found to my query.
I'm trying to understand how my ER-bound protein and its 3 interactors (also in ER) enter the nucleus.
If someone has experience and knowledge about this topic can you please help me with finding literature and understanding the problem I'm facing?
Dear Mateo Glumac ,
The following review pretty much summarized what is the current state of knowledge in this matter: Liu, Y., Li, P., Fan, L. et al. The nuclear transportation routes of membrane-bound transcription factors. Cell Commun Signal 16, 12 (2018). https://doi.org/10.1186/s12964-018-0224-3
https://biosignaling.biomedcentral.com/articles/10.1186/s12964-018-0224-3
Best regards
Dear Rob Keller,
thank you for the reply. I have already considered the paper you recommended. The major difference between described mechanism in the paper and my problem is that none of my proteins of interest are membrane-bound. They are all found in the lumen of ER.
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