As there are two methods for the intrahippocampal injection for the establishment of SE.

Kainic acid and pilocarpine.

which one is better?

As far as I know, the kainic acid is a typical model for TLE, while the direct injection of kainic acid will trigger the excitoxicity which make me have some questions upon this model. Like, the theory of this model is that inducing the epilepsy then result in the degeneration or the excitoxicity triggers the epilepsy?

Hope anyone could discuss with me about that interesting question. THX.