Hi Valerie,

look here:

Article Determination of sub-ppb epichlorohydrin levels in water by ...

Regards Markus

M;r. Nogueira,

By means of internal standard approach.

which ISTD will advise you?

Hi Valerie,

have you read the link I've posted here? You can't measure epichlorohydrine directly due to the fact, that this molecule doesn't ionize good under ESI conditions. You have to to do a derivatization as the first step. It also has low mass and high polarity. Therefore you also will have problems with chromatography. That's why you need derivatization. Thinking about an internal standard won't help you if you haven't solved the ionization problem.

Regards Markus

I agree with Markus. You might be able to separate the molecule with a specialty column but then there are the issues with the ionization. Either derivitization or shifting to a GC technique such as GC-MS are the way to go.

Thanks for yours responses.

Epichlorohydrin can be analyzed by GCMS quite easily.