Hello, when a patient is first infected with Ebola my understanding is that there is not really a primary viremia and for the first week Ebola just sits in the organs and or white blood cells nesting. Subsequent to this ~4-7 day stage ebola sheds into the circulatory system causing a full blown viremia that grows in time proportional to it mortality rate. This is when there are symptoms and antibodies, antigens, and virus to detect for diagnosis.
I also understand that there is a superficial primary viremia that occurs before and during ebola's nesting stage where there are 1-3 Ebola epitopes/antigens and human antibodies for this in vivo but very very diluted and therefore difficult to ascertain via current ex-vivo diagnostic techniques.
1.) What are these epitopes and antibodies during the primary viremia?
2.) How dilute are they in vivo, meaning what is there (and any Ebola particle) count during this primary stage?
3.) What is the minimum count for these to be detected via best current diagnostic techniques?
Thanks:)
· Dear Joel Subach
Pls. find the attached files .
http://cmr.asm.org/content/29/4/773.full
http://apps.who.int/iris/bitstream/10665/134009/1/WHO_EVD_GUIDANCE_LAB_14.1_eng.pdf
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1000212
http://www.nejm.org/doi/full/10.1056/NEJMoa1411100
http://cid.oxfordjournals.org/content/42/11/1521.full
https://www.ncbi.nlm.nih.gov/pubmed/26319169
http://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-ebola-virus-disease
http://www.sciencedirect.com/science/article/pii/S0956566315303651
http://www.who.int/mediacentre/factsheets/fs103/en/
http://www.cdc.gov/vhf/ebola/diagnosis/
Hoping this will be helpful
Regards
Prof. Houda Kawas
unfortunately I was not allowed by the embassies of Sierra Leone and Nigeria to treatcebola infected people.This would have demonstrated, that virusinfection can becstpped immediately by energetic trearment. The immunesystem iscactvated and, since virusreplication is stopped, the immunesytem eliminatescthe viruses andcthe patient ic immune for reinfection.
Hello and thank you for your reply,
I am not sure what you are suggesting since EBola's mark is a destruction of the immune system instead of vice versa.
Yes, this is the point: the virus is immediatly lnactivated by the treatment, so it will not contiue to destroy the immune-cells. A similar situation you hve with HIV infection, I could treat HIV patients effecrfully and I regret, they do not come, despite I offered to treat a few free of charge.
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