hi
I want to synthesize nanoparticle PLGA-PEG carrying doxorubicin and also some nucleic acid (mirna).
Between Doxorubicin (hydrophobic form) or Doxorubicin HCL ( hydrophilic form) which one should I use if i want to encapsulate it into PLGA-PEG conjugate with peptide
using double emulsion method w/o/w ( with w/o surfactant SPAN 80 and o/w Tween 80).
What is the benefit and pitfall of either these two forms of DOXORUBICIN
thank you appreciate the answer so much.
Hi Zaidah Ibrahim ,
Check attached picture and the below paper:
Babos, G., Biró, E., Meiczinger, M., & Feczkó, T. (2018). Dual drug delivery of sorafenib and doxorubicin from PLGA and PEG-PLGA polymeric nanoparticles. Polymers, 10(8), 895.
As seen in the attached picture, the FDA-approved drug contains Doxorubicin-HCL. There are also reports on the use of non-hydrochloride form of Dox in pharmaceutical formulations. Note that: The primary amine of doxorubicin (pKa~7.2-8.2) is positively charged at acidic pH. This makes the molecule more soluble and more easy to formulate (encapsulate).
thanks prof mozafari for the link.
Dr. omar- can you explain about hydrophobic choice? thanks in advance
Plga is hydrophobic and thus it sucks for encapsulating hydrophilic drugs, no matter what you do you cannot outwin physics. You need a hydrophobic drug then.
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