Can Temozolomide cure mice with xenografted intracranial gliomas?

TMZ is FDA approved for GBM in humans but its overall effectiveness is limited. In intracranial mouse xenografts of run-of-the mill GBM cell lines like U87, how well does TMZ perform? I.e. is it...

16 February 2017 969 5 View

Why Are Liver Cell lines Not Sensitive to Cyclophosphamide?

Cyclophosphamide is supposed to be activated by Cytochrome P450. I've treated Huh7 and PLC liver cancer cell lines with Cytochrome P450, but there is no sensitivity whatsoever, even at 500uM....

26 January 2017 7,250 5 View

How can I get my porcine chondrocytes to detatch from 24 well plates after 7 days of culture?

18 August 2016 7,366 3 View

PH versus pD versus pT of phosphate buffer?

02 August 2016 1,247 3 View

Is there an online manual available that details how to use the TWAIN image acquire system, especially with a Carestream 4000mm pro?

I am trying to figure out how to acquire images of x-ray film and western blots (using ECL) using the Carestream Image Station 4000mm with TWAIN and I can't find a manual or guideline anywhere...

18 August 2014 8,980 3 View

Does anyone know of a mouse specific antibody for a housekeeping gene?

I have xenografted human tumor lysates that I am running western blots on. I need to determine the extent of mouse cell contamination in these lysates (I don't have slides for the tumors). I am...

16 June 2013 3,679 7 View

A Survey on Human-Computer Interaction

A Human-Computer Interaction Research Group of Wuhan University is conducting an academic survey on search as learning on academic social networks, and they look forward to your participation....

01 January 1970 9,425 3 View

Does the pressure(-600 mmHg) affects pH?

When I conducted the degassing experiment using decompression under anaerobic condition(and I used ferrous based chelating agent), the oxidized ferric were observerd. So, could you tell me the...

03 March 2021 4,892 5 View

Why can't make aluminum nitride film successfully by use sputter?

We use reactive sputtering process to make aluminum nitride film, and want to make c-axis aluminum nitride film on a silicon substrate, but the crystal orientation cannot be seen with...

03 March 2021 7,975 3 View

Is there any test to determine the cardiovascular risk of patients with obesity? from the perspective of obesity?

We found tests to determine cardiovascular risk taking into account lipid profile, blood pressure, age, history of diabetes, other laboratories. But when weight is involved, there is a paradox. I...

02 March 2021 6,036 1 View

Why are the velocities so high in my Boussinesq approximation Fluent simulation?

Hello, I have a mechanism where air rises due to convective flows. In this simulation, nothing is driving the air except this. I understand that the Boussinesq approximation only works for small...

02 March 2021 4,910 3 View

Why almost every element would be metallized in sufficiently high pressure and low temperature?

(This statement is from wikipedia, BTW). What is so special about metallic bond that is limiting high-P low-T state of a matter (as long as individual atoms exist, not white dwarf of neutron star...

02 March 2021 3,309 2 View

Sutter electrode holder leaking after applying positive pressure. How to fix?

I am using a Sutter electrode holder for my patch clamp experiments, but I'm having trouble keeping positive pressure inside my electrode due to a leak out of the back of the holder. I have added...

02 March 2021 5,829 1 View

What SPSS analysis should I run with one IV (with two levels) and two DVs?

Hi, I am trying to figure out which test would be most appropriate to run for the following question: Is there a difference in task blood pressure between smokers and non-smokers? There are two...

01 March 2021 8,235 2 View

How much pressure we can reduce at the outlet to avoid Reverse Flow?

I am simulating Heat Exchanger. I have tried and tested all the methods to resolve this issue from the internet like refining mesh, improving skewness and orthogonal quality ,extending outlet to...

01 March 2021 6,985 3 View

Exit velocity of natural gas from pressurized tank?

Hi Guys. I'm a mechanical engineer and have a bit trouble, would be very glad if you could help me with my questions. I have a pressurized tank which contains Natural Gas at 200 Bar and 293...

26 February 2021 6,253 3 View

CGA 300 Regulator for CO2 cylinder?

Has anyone ever tried to deliver CO2 with a CGA 300 regulator? I know that a CGA 320 regulator is standard for CO2. The issue is that I currently do not have any free CGA 320 regulators. I also...

25 February 2021 3,292 3 View