Does Type I IFN increase ROS production from the mitochondria and cellular senescence ?

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Peramaiyan Rajendran

oxidative

stress-mediated DNA damage, through induced NADPH oxidases

and repression of ANT2, represent a key and shared feature

downstream of diverse senescence-inducing cytokines, including

those produced by cells of the immune system such as IFN

Ravichandran Panchanathan

thanks