Hi !

Does the fragility of cells to hypoxia of anoikis depends on their history ?

Meaning if some cells are exposed to very low levels of oxygen or are put without ECM, and then put again in good condition, and then put again in hypoxia or anoikis situation, are they going to be the second time less resistant ? Is there memory and if yes for how long ?

Would you have references for that please ?

Thank you in advance