In recent days hiPSCs are a better tool for studies of the pathophysiology and cellular responses to therapeutic agents and it is supposed to be the cutting-edge technology of cell therapy. But my curiosity is to know how much it will be safe. How we would be assured that disease phenotype will not appear in the reprogrammed iPSCs?
Tony Andrew Piper
You should not use diseased cells for therapy. either correct the disease in the cells (e.g CRISPR/Genome editing - and sequence verify) before using as a therapy, or better still make iPSCs from non-diseased 'normal' donor - will still need sequence verification to ensure are safe to use...
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Rayhanul Islam Shimul
Thank you so much for your kind information.@Tony Andrew Piper.
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