Hi,
I would like to know if inflammation stimulates or inhibits gluconeogenesis. Inflammation is known to trigger insulin resistance, which should lead to an increased gluconeogenesis since insulin inhibits gluconeogenesis. However, some papers claim that inflammation decreases gluconeogenesis. Does someone have a good knowledge of this phenomenon and could help me ?
Thank you.
Glucocorticoids stimulate the process of hepatic gluconeogenesis, resulting in elevated plasma glucose, which, in turn, promotes the deposition of liver glycogen. Increased hepatic gluconeogenesis/glycogenesis is due to direct effects of glucocorticoids on the hepatic expression of genes that code for enzymes required for glucose and glycogen biosynthesis. Hence inflammation decreases gluconeogenesis
Glucocorticoids including cortisol which is counter-regulatory to insulin stimulate gluconeogenesis. Glucocorticoids are inflammatory and stimulate reactive oxidative species(ROS) which further damage the system by down regulating the uncoupling inflammatory proteins (UPS) which would have stabilized the metabolic system by forcing glycolysis to suppress gluconeogenesis and force more insulin to be produced instead of cortisol, et al. Remember unregulated gluconeogenesis causes increased glucose in the blood and reduced insulin sensitivity.
Thank you for answers.
To be more specific, if for example we have a mutant mouse model which presents chronic systemic inflammation, would you say that it has increased or decreased gluconeogenesis compared with a wild-type mouse ?
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