I did not investigate the issue described in the article below much but if you are going to investigate codon bias you should probably familiarize yourself with the issue discussed in that field.
http://www.nature.com/doifinder/10.1038/nmeth1110-874
Thank you very much Dr. Jens Allmer. I will go through this article.
Regarding whether codon bias have influence on translation elongation rate, there's a comprehensive genome-wide study in yeast (http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002603 , I'm one of the authors), which shows no evidence for it.
There's plenty of evidence for codon bias influencing translational accuracy though.
Thnak you Dr. Jianrong Yang. It works good for the known class of proteins. Still no evidence on its accuracy. Thank you Dr.
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