After antigen exposure, human CD8+ T cells loose CD28 and acquire CD57 molecule. Does CD57 perform any function (receptor or something similar...)?
Dear Dainius, let me know more about your experimental design. What is the source of your CD8+ cells (MNC, cell line, clone?) What is activation (infection, anti-CD3, mitogen, antigen-loaded APC, peptide, allogenic cells?) How long time after activation is required to observe the effect?
Dear Dmitry, we observe loss of CD28 and acquisition of CD57 on CD8+ T cells in humans. It is not only our observation, but it is described in literature.
Dear Dr. Dmitry B. Kazansky,
I have just found an article describing the association of lower CD57+ frequencies in CD28-CD8+ T cells to higher mortality in HIV-infected patients. This suggests that CD57 might be functionally important, although the observed association could be indirect because of a lot of other factors involved in the effector T-cell function. It should be interesting to investigate the function of CD57 in T cells.
Article Low Proportions of CD28(-) CD8(+) T cells Expressing CD57 Ca...
Regards,
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