Does anyone work on the role of HDAC6 in microtubule stability and mitochondrial transport in axons?

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Georg Haase

The group of Ludo van den Bosch at University Leuven, Belgium has published a very nice study on HDAC6 in CMT neuropathy. Do not hesitate to contact him with your specific question. Best

http://www.nature.com/nm/journal/v17/n8/abs/nm.2396.html

Syed Zahid Ali Shah

Thanks ever so much George and i have that paper with me..i will do as you suggested...

Go J Yoshida

HDAC6 is a microtubule-associated deacetylase, which impairs the transport function of microtubule especially in neuronal axons. Tubulin and Septins work in cooperation each other to form axon protrusion and dendritics. Neither too stabilized nor unstable microtubulues are unfavorable for those changes in neurons with plasticity. HDAC6 has recently been revealed that Septins work as a scaffold molecule for deacetylyzation of microtubules by HDAC6, thereby regulating the appropriate level of stability of microtubules.

Article Septins promote dendrite and axon development by negatively ...