Aortic dissection is disease of media. So detecting medial changes like loss of elastic fiber could be of great clinical importance. If we can detect this kind of degeneration by CT RI or MRI, that will be great progress. Does anyone know the modality to detect medial degeneration of aortic wall?
Dear satosh
Simply You can prepar a histological sections from the aorta and stain them by different stains like
1. Haematoxylin and eosin stain to see the degeneration and general structure of the aorta
2. Ver-hoff's stain to demonesterate elastic fibers black color
3. Van Gieson stain to demonstrate the elastic fibers yellow color
4. Toludine blue als can demonstrate elastic lamina
I already do a research about aortic atherosclerosis. You can see it in my home
by histological preparation of aortic specimen, sectioning ,and staining by different stains as:
- Haematoxylin and eosin stain to see degenerations and general structure of the aorta
- Orcine stain to demonesterate elastic fibers reddish brown color
I interpret the question to be "clinical", about evaluating a LIVE human. If so, I know of no direct method, although a spiral hi-definition CT with & without contrast may give useful information. Cystic medial necrosis is usually associated with some overall stretch of the wall that can be picked up. In Marfan's syndrome, a baseline CT should always be done.
Thank you for Doctors answered my question.
Sorry for confusion about LIVE or Histological. What I imagined was LIVE evaluation like CT MRI kind of modality. So Dr, Pate answered my question. Thank you very much.
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