Does anyone know of Gram negative bacteria producers of antibiotic that inhibit growth of Nocardia spp.? This Gram negative bacteria is airborne and grow well in nutrient media.
Antagonistic Activity of Nocardia brasiliensis PTCC 1422 Against
Isolated Gram-negative Bacteria from Urinary Tract Infections
Hossnieh Kafshdar Jalali1
, Khosro Issazadeh2
*, Mohammad Reza Majid
Khoshkholgh Pahlaviani3, Naeem Momeni4 and Alireza Massiha5
1,2,4Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University,
Lahijan Branch, Lahijan, P.O. Box 1616, Iran. 3,5Department of Biotechnology, Faculty of Basic Sciences,
Islamic Azad University, Lahijan Branch, Lahijan, P.O. Box 1616, Iran.
(Received: 08 March 2014; accepted: 15 April 2014)
The nocardiae are bacteria belonging to the aerobic actinomycetes. They are
partially acid fast, Gram-positive, branching filamentous bacteria that are found
ubiquitously in soil, fresh water and marine water. Bacterial urinary tract infections are frequent in the outpatient as well as in the nosocomial setting. The common bacteria from UTIs were isolated from hospital and laboratory samples. The present study was designed to isolate Gram- negative bacteria from urinary tract infections and evaluate Nocardia brasiliensis PTCC 1422 antimicrobial activity against pathogenic bacteria. Bacterial isolates were identified as Acinetobater spp. and Pseudomonas aeruginosa. The cell free supernatants of the N. brasiliensis were able to inhibit the growth of all human pathogens (Acinetobater spp. and Pseudomonas aeruginosa) isolated in this study in Well diffusion method. The isolates also showed very promising activities against multi drug resistant human pathogens.