Does anyone know about maximum tolerable and safe concentration of magnesium administered intravenously?
See link below.
http://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#h8
In adults, up to 150 mg/minute or 125 mg/kg/h using a 20 mg/mL solution (usually up to 2 g/h) can be administered for magnesium deficiency. See http://bestpractice.bmj.com/best-practice/monograph/1137/emergencies.html for more information.
The rate of I.V. injection should generally not exceed 150 mg/minute (1.5 mL of a 10% concentration or its equivalent), except in severe eclampsia with seizures.
In severe pre-eclampsia or eclampsia, the total initial dose is 10 to 14 g of magnesium sulfate. Intravenously, a dose of 4 to 5 g in 250 mL of 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP may be infused. please refer http://www.globalrph.com/magnesium_dilution.htm for further information.
to prevent seizures associated with pre-eclampsia, and for control of seizures with eclampsia
4-5 g (diluted in 250 mL NS/D5W) IV in combination with either (a) up to 10 g (10 mL of undiluted 50% solution) divided and administered IM into each buttock or (b) after initial IV dose, 1-3 g/hr IV
Do not exceed 20 g/48 hr
http://reference.medscape.com/drug/mgso4-magnesium-sulfate-344444
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