More specifically, the desired assessment should target the use of these compounds as flocculants and coagulants to limit erosion (i.e. export of suspended solids) from construction sites/activities nearby water bodies.
I am sure you did a research in the internet, anyway I found this document, may be could help you http://echa.europa.eu/documents/10162/50218bf9-ba0f-4254-a0d9-d577a5504ca7,
as far as polyacrylamide seems to be toxic it is recommended to use it with exctreme care .polymerization with bis acrylamide needs also care
I have some results for acrylamide, i hope it will help you.
Upon single exposure, acrylamide is toxic or harmful by all routes of administration. The principal effects prior to death relate to neurotoxicity, although severe effects on spermatid development were also noted. Acrylamide is a skin irritant, with skin peeling being a particular problem. Data are limited, but suggest that it should be considered as an eye irritant. There is clear evidence for skin sensitisation potential, but no data available regarding respiratory sensitisation. The principal effect observed as a result of repeated exposure, by all routes, is peripheral neuropathy including effects such as loss of use
of limbs, tremor, loss of balance and loss of axons and ganglion cells, as well as other degenerative changes in peripheral and optic nerves, and degeneration of the lateral geniculate nucleus. However, the dose-response information from humans is inadequate and the clearest information available is from rodent studies. Histopathology has indicated peripheral nerve lesions at 2 mg/kg/day, and no effects at 0.5 mg/kg/dayina2-yearrat study. Additionally, degeneration of spermatids and spermatocytes was observed amongst animals receiving approximately 36 mg/kg/day for 8 weeks, although this study was not designed to identify a NOAEL.
Dear Marc,
Under an ecotoxicological point of view, there are some indications that acrylamide may pose significant threats, likely following prolonged exposure to "low" concentrations, to aquatic vertebrates and invertebrates. By low concentrations I mean a few mg/L (ca. 1-10), which is found only at wastewater outlets. We have a publication coming out soon with a study on mussels. I'll render it available as soon as possible. The main effects we found so far relate to oxidative stress and gonadotoxicity, in females. However, the effects of chronic exposure in aquatic wildlife are not yet well understood. In general, acrylamide acute toxicity is low (e.g. LC50 = 400 mg/L in some freshwater fish).
Cheers
Pedro
Tissue distribution and pharmacokinetics of stable polyacrylamide nanoparticles following intravenous injection in the rat
Toxicology and Applied Pharmacology
Volume 251, Issue 3, 15 March 2011, Pages 181–190
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