I am interested in finding studies which have conditioned drug effects in humans.
ie paired a UCS-CS and evoked a CR with the CS. There are some older studies but this seems to have dropped out of view in recent years. There are of course, numerous animals studies.
Dear Kerrie,
Check these out:
Benedetti F, Pollo A, Lopiano L, et al. Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses. J Neurosci. 2003;23(10):4315-4323.
Haour, F. Mechanisms of the placebo effect and of conditioning. Neuroimmunomodulation. 2005;12:195-200.
Amanzio M, Benedetti F. Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. J Neurosci. 1999;19(1):484-494.
Several possibly helpful articles are attached.
Best,
TJ
http://www.jneurosci.org/content/27/51/14035.full.pdf+html
http://www.ncbi.nlm.nih.gov/pubmed/16503701
Article Cue dependency of nicotine self-administration and smoking
Dear Kerrie, a PubMed search for "conditioning effect of drugs AND conditioning [TITLE] AND drug [TITLE]" reveals numerous and even newer publications. One area where there are many studies is dependency and addictions. Nevertheless, as you wrote, most studies on this topic are of older date. I think this is also due to the simple fact that nowadays classic experimental studies for proofing this effect are no longer approved by the ethics committees. Please find below a couple of items that - in my pesonal opinion - are interesting to read.
- Robbins SJ, Ehrman RN. (1992). Designing studies of drug conditioning in humans. Psychopharmacology (Berl). 106(2):143-53.
- Stockhorst U, Mahl N, Krueger M, et al. (2004). Classical conditioning and conditionability of insulin and glucose effects in healthy humans. Physiol Behav. 81(3):375-88.
- Attwood A, Terry P, Higgs S. (2010). Conditioned effects of caffeine on performance in humans. Physiol Behav. 99(3):286-93.
Some useful citation:
Tiffany ST, Cox LS, Elash CA. Effects of transdermal nicotine patches on
abstinence-induced and cue-elicited craving in cigarette smokers.
J Consult Clin Psychol 2000;68:233 – 240.
Caggiula AR, Donny EC, White R, Sved A, Gharib M, Maldovan V, Booth
S, Chaudhri N. The role of environmental cues in the acquisition,
extinction and reinstatement of nicotine self-administration. Soc Neurosci
Abstr 2000;26:192 – 194.
and
http://www.em-consulte.com/article/83454/alertePM#N100A3
Verônica
Thank you everyone for all your helpful suggestions. Many many thanks!
Another reference that may be helpful:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467981/pdf/pone.0128997.pdf
Verônica
It's difficult to do these studies in humans (developing tolerance & withdrawal ot particular stimuli)
Here are a couple of studies (sorry if these are redundant):
Classical conditioning in humans: nicotine as CS and alcohol as US. in Human Psychopharmacology, 11(2) 85-95 1996
Also
Are we dependent upon coffee and caffeine? A review on human and animal data. in Neuroscience and biobehavioral reviews, 23(4) 563-576 1999
See also GOEBEL, M. U., TREBST, A. E., Steiner, J. A. N., XIE, Y. F., EXTON, M. S., FREDE, S., ... & SCHEDLOWSKI, M. (2002). Behavioral conditioning of immunosuppression is possible in humans. The FASEB journal, 16(14), 1869-1873.
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