Yes, I have. There is a great review in the JNCI in 2014 by Pilarski that you might look at for new information regarding risk. Another interesting aspect in the future will be how panel testing  might change our understanding of such relatively rare syndromes. Cowden's or PTEN affected patients usually have a large head circumference, but ours did not. It will be interesting to see whether widespread panel testing changes the incidence of such phenotypic changes.

Thanks Dr Elboim and we here from you each new information.

Dear Dr.Bashir,

You can find some useful information and an interesting discussion here:

http://icvts.oxfordjournals.org/content/1/2/78.full

Best regards

Dear Scanagatta

Thanks for a valuable information.

Dear Dr. Bashir, 

we recently diagnosed a case of hamartoma tumor syndrome in a young boy affected by  macrocephaly and multiple vascular malformations. I enclose the references that we used to study the case.

Best regards

Dear Dr Gironi Thanks for your concern