Looking for mouse models with progeria. Does anyone know where to purchase them?
Might this model be suitable for you? Http://jaxmice.jax.org/strain/010667.html
generally, looking for any mouse model, I found this databank really useful.
http://www.informatics.jax.org/
It gives nice overview on existing models, groups which developed and published them and often also a company to purchase them.
If it's the LMNA gene you're looking for, try the international mouse strain resource: http://www.findmice.org/summary?query=LMNA&states=ES+Cell&states=embryo&states=live&states=ovaries&states=sperm&_states=1&types=Any&_types=1&repositories=Any&_repositories=1&_mutations=on
If it's a different strain you're after, the website is still a good one to bookmark for the future.
Best wishes, B
As others have stated Jackson labs is a great place to go. You can probably obtain these mice from other researchers using them for free (just the cost of shipping), however, and should consider that option. Keep in mind the the LMNA -/- mice are not a good progeria model. A much better model is the ZMPSTE24 -/- mouse. In Hutchinson-Gilford progeria it is a mutation in LMNA that results in aberrant processing and accumulation of the farnesylated form of this protein. In the LMNA -/- mice they simply lack lamin a altogether. ZMPSTE24 is an enzyme involved in LMNA processing and loss of it results in accumulation of LMNA, more closely modeling the human disease.
- Badges
- Science topic
- Similar topics
- Biological Science
- Immunology