In general formalin and high temperatures with different solvents to put specimens in paraffin causes DNA degradation . However, there are many experiences in this field and the results were stunning .
you can do that provided that consider the age of the block and choose the best technique & kit for your sample .There are multitude of techniques (real time PCR , qPCR, Microarray, Western-Blot,...) and need to have the structural/morphological information of paraffin-embedded .
We can help you best if Identified the type of cancer tissue & analysis you use in your studies