Reviewing the literature shows that the inclusion complex, obtained by co-precipitation method between a pigment (curcumin, bixin…) and cyclodextrin, is usually washed with solvent (ethanol/acetone) and water to remove the uncomplexed pigment and CD, respectively, before frozen and lyophilized the powder.
So far as I know, the solvent is used to repeated extraction of the included pigment in order to quantify the encapsulation efficiency. In the other hand, the obtained complex is totally soluble in water.
So, how is possible washing the precipitate without the completed dissolution of the inclusion complex?
Hello Martina, when you make the inclusion complex (IC) using the CP method, there could be a free API /pigments like curcumin. Most likely, the API would be hydrophobic so one of the approach that might work can be dissolving the CP product in water and the obtain the water soluble IC. Free API being hydrophobic would no dissolve in water.
Hello Abhishek Gupta, thanks for reply. OK...the API won't dissolve in water but the CP product will. In this way i won't have the CP in powder form anymore. I was hoping to purify the CP powder obtained.
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