We have recently published 2 experimental studies that show positive inotropic effect of the PDE3 inhibitor milrinone and the calcium sensitizer levosimendan during hypothermia and rewarming. This is different from studies on B-receptor agonists like epinephrine and isoprenaline, which show that such drugs have diminished or negative inotropic effects during hypothermia.
I therefore want to know whether anyone have clinical experience with use of PDE3 inhibitors or calcium sensitizers in patients that are treated with therapeutic hypothermia (eg. during surgery or after cardiac arrest) or during rewarming from accidental hypothermia?
Milrinone ameliorates cardiac mechanical dysfunction after hypothermia in an intact rat model: http://www.ncbi.nlm.nih.gov/pubmed/25224046
Cardiovascular effects of levosimendan during rewarming from hypothermia in rat: http://www.ncbi.nlm.nih.gov/pubmed/25280932
my experience is the clinical data of kidney stones and gall bladder stones with hypercalcemia in primary hypothyroidism with duodenal kissing ulcer and renal acidosis in the same patient with goitrous polyseritis.
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