Does anyone have clinical experience with Pirfenidone in hepatic fibrosis?

More Joel Cazares's questions See All

What are the research gaps for telematic technologies for road pavements optimization?

what can be the undiscovered benefits of applying telematic technologies for road pavement maintenance, incident reduction and environmental protection?

29 June 2024 7,507 1 View

Why am i getting the human verification when i search for certain topic?

most of the time when i search fo certain topic i found the human verification respond and nothing change there after

19 March 2024 6,870 0 View

How to handle twins in birth order analysis?

Hello! I have a methodological question and I hope someone can help me. I collected data via an online survey with a sample size of 2600 (N = 2600). Initially, I aimed to examine the effect of...

26 February 2024 6,911 4 View

FfTK Calc Bonded Tab ORCA gbw file not recognized INQUIRY?

Hi RG Community I had input all the appropriate files, however, received an Action halted on error! My ORCA generated .gbw QM Output file was not recognized (please see screenshot attached). I...

15 February 2024 2,553 1 View

How long would it take a biofiltratration sysytem in fish culture to complete the nitrogen cycle?

Typically, it is said that biofilter by their nature allow the settling of bacteria beneficial to the treatment of fishwaste. Fish culture though is known for producing high amounts of ammonia in...

28 January 2024 2,398 3 View

Why do eastern European nations seem to have a significantly lower all-cause mortality rate than the UK, Canada, and the U.S.?

From what I can tell by searching the "Your World in Data" website, eastern Europe seems to have an expected lower than average all-cause mortality rate than the western first world nations, who...

04 January 2024 7,066 0 View

Topology Validation Inquiry within an .str File via CGenFF Inquiry?

Hello RG Community:), I have a ligand exhibiting penalties between 10-50 within a .str file generated via a CGenFF, the generated .prm file does not exactly match the ligand atoms nor the closest...

25 December 2023 4,364 1 View

Alphafold Monomer versus MODELLER Oligomer Loop Modeling Inquiry?

Hi I had modelled a heptamer transmembrane protein missing 10-residues within the extracellular loops via MODELLER constraining the known residues as a heptamer (when MODELLER modeled as a monomer...

08 December 2023 4,512 0 View

AlphaFold Multimer Loop Modeling Inquiry?

Hello towards the above topic, I successfully loop-modeled a transmembrane heptamer protein (426-residues per monomer) exhibiting 7-extracellular loops each missing 11-residues via MODELLER via...

03 December 2023 9,528 2 View

Need a simulation tool to generate synthetic data 🙏?

Need a simulation tool to generate synthetic data Specialized engine simulation software (for control and diagnosis) how and what to do 🙏?

16 November 2023 4,128 1 View

Is there a problem with my RNA pellet?

Hello, I am currently having problems with RNA extraction. I am using mouse liver (C57BL6J), and I have extracted RNA from mouse liver before. Before this experiment, my final RNA pellets were...

11 August 2024 7,082 3 View

Tissue homogenization in mouse with FastPrep-24™ 5G - is the D matrix system useful?

I need to lyse and homogenise mouse tissues. So far I have experimented with liver and lung tissue, using matrix D. The liver was completely lysed with 6 repetitions of the standard program, but...

31 July 2024 9,186 0 View

Does anyone notice the tumor regression impact of Hepa1-6 cells in HCC orthotopic mice model?

To establish an orthotopic HCC model, C57BL/6 mice (male, 6-8 weeks) were orthotopically implanted with 3x106 Hepa1-6 cells (Over-expressed with a human gene) in 20uL Matrigel into the left lobe...

18 July 2024 9,177 2 View

Why is the baseline fibrosis level of HK-2 cells very high?

In many experiments where HK-2 cells were stimulated with TGF-β at 10 ng/mL for 48 hours, I observed that even in the control group, the baseline expression level of fibrosis proteins like FN1 and...

15 July 2024 1,929 2 View

How can I put an alert to receive notifications of call for papers in my research field?

I'd like to receive notifications of call for papers for any journal pertaining to my expertise (immunology, rheumatology, immuno-mediated liver involvement) from researchgate. Thanks in advance...

01 June 2024 1,352 0 View

Where can I get some Bipotent Mouse Embryonic Liver (BMEL) cells ?

Reference for BMEL cells : Inducible differentiation and morphogenesis of bipotential liver cell lines from wild-type mouse embryos Hélène Strick-Marchand, Mary C Weiss doi:...

29 May 2024 7,198 0 View

Inconsistente results with cell line LX-2, any advice?

Hi there! I'm working on my master's thesis and for my project I'm testing a new curcumin derivative in liver fibrosis. I'm working with the cell line LX-2 and have been having problems since the...

21 May 2024 2,171 0 View

What are the most recent advancements in understanding and treating hepatocellular cancer (HCC) based on the latest research findings?

What are the most recent advancements in understanding and treating hepatocellular cancer (HCC) based on the latest research findings? How do recent breakthroughs in molecular oncology and...

10 May 2024 1,678 2 View

Recommendation for pretreatment of pup mouse liver for FFPE tissue?

Can anyone recommend fixation techniques for neonatal mouse livers? We usually fix our adult-derived organ sections (about 0,5-1cm in length and 3-4mm in thickness) in 4% PFA for 48 hours at RT,...

08 May 2024 8,349 1 View

How to measure adherence in a surveillance programme?

A population afflicted with liver disease, putting them at risk of cancer, undergoes surveillance to detect cancer at its earliest stages. The recommended protocol involves ultrasound screenings...

07 May 2024 9,340 0 View