Hi Stephanie,

The following reference will be helpful to you.

Rostovtsev, V. V., Green, L. G., Fokin, V. V. and Sharpless, K. B. (2002), A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes. Angewandte Chemie International Edition, 41: 2596–2599. 

Good luck.

Hi Stephanie,

What scale are you working on? You could try carrying it out in a reactivial or even a small sample vial.

Cheers,

Ian

I assume that CuI/Br, DMF, ultrasonication (eg. cleaning bath) would worth an attempt. If you can use a MW reactor then Cu powder/DMF + MW.

Ok - So my advice for anyone else venturing into click chemistry is to make sure you follow the sharpless concentrations exactly (if you plan to use that method). Small sample vials work well and benchtop reactions can take upto 48hrs to get a good yield. The main thing is concentration of reagents.